Theory of evolutionary molecular engineering through simultaneous accumulation of advantageous mutations.

Abstract excerpt

We examined the effectiveness of an "adaptive leap" strategy using the "mutation scrambling" method as an efficient optimization technique (Uchiyama, 2000;J. Biochem.128, 441-447) for cases where mutational (rough) additivity holds in fitness. The mutation scrambling method is composed of the following three processes: (1) preliminary selection of several advantageous single-point mutations introduced in a...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Biopolymers
• Share to Evolution, Molecular
• Share to Models, Genetic