Article
Contribution of known and unknown susceptibility genes to early-onset diabetes in scandinavia: evidence for heterogeneity.
Diabetes - 1 May 2002
Lindgren Cecilia M, Widén Elisabeth, Tuomi Tiinamaija, Li Haiyan, Almgren Peter, Kanninen Timo, Melander Olle, Weng Jianping, Lehto Markku, Groop Leif C
Abstract excerpt
In an attempt to identify novel susceptibility genes predisposing to early-onset diabetes (EOD), we performed a genome-wide scan using 433 markers in 222 individuals (119 with diabetes) from 29 Scandinavian families with > or =2 members with onset of diabetes < or =45 years. The highest nonparametric linkage (NPL) score, 2.7 (P < 0.01), was observed on chromosome 1p (D1S473/D1S438). Six other regions on...
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