Article
Contribution of rare variants in monogenic diabetes-genes to early-onset type 2 diabetes.
Diabetes & metabolism - 1 Sept 2022
Pezzilli Serena, Tohidirad Manoush, Biagini Tommaso, Scarale Maria Giovanna, Alberico Federica, Mercuri Luana, Mannino Gaia Chiara, Garofolo Monia, Filardi Tiziana, Tang Yaling, Giuffrida Fernando, Mendonca Christine, Andreozzi Francesco, Baroni Marco Giorgio, Buzzetti Raffaella, Cavallo Maria Gisella, Cossu Efisio, D'Angelo Paola, De Cosmo Salvatore, Lamacchia Olga, Leonetti Frida, Morano Susanna, Morviducci Lelio, Penno Giuseppe, Pozzilli Paolo, Pugliese Giuseppe, Sesti Giorgio, Mazza Tommaso, Doria Alessandro, Trischitta Vincenzo, Prudente Sabrina
Abstract excerpt
AIM: This study investigated whether rare, deleterious variants in monogenic diabetes-genes are associated with early-onset type 2 diabetes (T2D). METHODS: A nested case-control study was designed from 9712 Italian patients with T2D. Individuals with age at diabetes onset ≤35 yrs (n = 300; cases) or ≥65 yrs (n = 300; controls) were selected and screened for variants in 27 monogenic diabetes-genes by targeted...
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