Article
A genome-wide scan in families with maturity-onset diabetes of the young: evidence for further genetic heterogeneity.
Diabetes - 1 Mar 2003
Frayling Timothy M, Lindgren Cecilia M, Chevre Jean Claude, Menzel Stephan, Wishart Marie, Benmezroua Yamina, Brown Alison, Evans Julie C, Rao Pamidghantam Subba, Dina Christian, Lecoeur Cécile, Kanninen Timo, Almgren Peter, Bulman Michael P, Wang Youxiang, Mills James, Wright-Pascoe Rosemarie, Mahtani Melanie M, Prisco Francesco, Costa Angels, Cognet Ignacio, Hansen Torben, Pedersen Oluf, Ellard Sian, Tuomi Tiinamaija, Groop Leif C, Froguel Philippe, Hattersley Andrew T, Vaxillaire Martine
Abstract excerpt
Maturity-onset diabetes of the young (MODY) is a heterogeneous single gene disorder characterized by non-insulin-dependent diabetes, an early onset and autosomal dominant inheritance. Mutations in six genes have been shown to cause MODY. Approximately 15-20% of families fitting MODY criteria do not have mutations in any of the known genes. These families provide a rich resource for the identification of new MODY...
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