Article
Short telomeres are sufficient to cause the degenerative defects associated with aging.
American journal of human genetics - 1 Dec 2009
Armanios Mary, Alder Jonathan K, Parry Erin M, Karim Baktiar, Strong Margaret A, Greider Carol W
Abstract excerpt
Telomerase function is critical for telomere maintenance. Mutations in telomerase components lead to telomere shortening and progressive bone marrow failure in the premature aging syndrome dyskeratosis congenita. Short telomeres are also acquired with aging, yet the role that they play in mediati...
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