Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterozygous telomerase deficiency in mouse and man: when less is definitely not more.

Cell cycle (Georgetown, Tex.) - 1 Sept 2004

Mason Philip J, Bessler Monica

Abstract excerpt

Telomerase, whose core components are a reverse transcriptase (TERT) and an integral RNA (TERC) maintains telomere ends. In somatic cells in the absence of telomerase telomeres get shorter leading to replicative cell senescence. In cancer cells abundant telomerase is present and cells do not senesce. Hence levels of telomerase may be crucial in regulating senescence and the transition to the neoplastic state....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Transformation, Neoplastic
Share to Cellular Senescence
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dyskeratosis Congenita

Share to Haplotypes

Share to Telomerase

Share to Telomere

Source

Identifiers

PMID: 15326392

Genes

TERT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygous telomerase deficiency in mouse and man: when less is definitely not more.PMID 15326392Read ↗

Human diseases of telomerase dysfunction: insights into tissue aging.Semantic proximity Read ↗

Regulation of human telomerase in homeostasis and disease.Semantic proximity Read ↗

Expression of Telomerase RNA Template, but Not Telomerase Reverse Transcriptase, Is Limiting for Telomere Length Maintenance In VivoSemantic proximity Read ↗

Telomerase reverse transcriptase-dependent telomere equilibration mitigates tissue dysfunction in mTert heterozygotes.Semantic proximity Read ↗

Differential impact of a dyskeratosis congenita mutation in TPP1 on mouse hematopoiesis and germlineSemantic proximity Read ↗

Triallelic and epigenetic-like inheritance in human disorders of telomerase.Semantic proximity Read ↗

Molecular mechanisms of telomere biology disorders.Semantic proximity Read ↗

Current Insights to Regulation and Role of Telomerase in Human DiseasesSemantic proximity Read ↗

Functional characterization of novel telomerase RNA (TERC) mutations in patients with diverse clinical and pathological presentations.Semantic proximity Read ↗

Telomerase deficiency and cancer susceptibility syndromes.Semantic proximity Read ↗

Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase.Semantic proximity Read ↗

Medical genetics and epigenetics of telomerase.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.