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Article

C-terminus of p53 is required for G(2) arrest.

Oncogene - 27 Mar 2002

Nakamura Seiichi, Gomyo Yoshihito, Roth Jack A, Mukhopadhyay Tapas

Abstract excerpt

Mutation of four lysine residues in the p53 C-terminal domain inhibits MDM2-dependent ubiquitination of p53 and alters its subcellular distribution. This implies that modification (such as acetylation and phosphorylation) of amino acid residues in p53 C-terminal domain, regulate the biological functions of p53. In this study, we demonstrated that p53 with lysine residues 372, 373, 381, and 382 mutated to alanine...

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Source

Identifiers

PMID: 11960383
DOI: 10.1038/sj.onc.1205251

Genes

MDM2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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C-terminus of p53 is required for G(2) arrest.PMID 11960383Read ↗

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p53 C-terminal phosphorylation by CHK1 and CHK2 participates in the regulation of DNA-damage-induced C-terminal acetylation.Semantic proximity Read ↗

COOH-terminal domain of p53 modulates p53-mediated transcriptional transactivation, cell growth, and apoptosis.Semantic proximity Read ↗

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.Semantic proximity Read ↗

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