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Article

Multiple C-terminal lysine residues target p53 for ubiquitin-proteasome-mediated degradation.

Molecular and cellular biology - 1 Nov 2000

Rodriguez M S, Desterro J M, Lain S, Lane D P, Hay R T

Abstract excerpt

In normal cells, p53 is maintained at a low level by ubiquitin-mediated proteolysis, but after genotoxic insult this process is inhibited and p53 levels rise dramatically. Ubiquitination of p53 requires the ubiquitin-activating enzyme Ubc5 as a ubiquitin conjugation enzyme and Mdm2, which acts as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11046142
DOI: 10.1128/MCB.20.22.8458-8467.2000
PMCID: PMC102152

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-11046142-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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