Article
Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptase.
Antimicrobial agents and chemotherapy - 1 May 2002
Meyer Peter R, Matsuura Suzanne E, Tolun Adviye A, Pfeifer Ingrid, So Antero G, Mellors John W, Scott Walter A
Abstract excerpt
Nucleotide-dependent unblocking of chain-terminated DNA by human immunodeficiency virus type 1 reverse transcriptase (RT) is enhanced by the presence of mutations associated with 3'-azido-3'-deoxythymidine (AZT) resistance. The increase in unblocking activity was greater for mutant combinations associated with higher levels of in vivo AZT resistance. The difference between mutant and wild-type activity was...
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