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Article

Allosteric regulation of HIV-1 reverse transcriptase by ATP for nucleotide selection.

PloS one - 25 Jan 2010

Yokoyama Masaru, Mori Hiromi, Sato Hironori

Abstract excerpt

BACKGROUND: Human immunodeficiency virus type 1 reverse transcriptase (HIV-1 RT) is a DNA polymerase that converts viral RNA genomes into proviral DNAs. How HIV-1 RT regulates nucleotide selectivity is a central issue for genetics and the nucleoside analog RT inhibitor (NRTI) resistance of HIV-1. METHODOLOGY/PRINCIPAL FINDINGS: Here we show that an ATP molecule at physiological concentrations acts as an...

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Identifiers

PMID: 20111609
DOI: 10.1371/journal.pone.0008867
PMCID: PMC2810339

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