Article
Locations of anti-AIDS drug binding sites and resistance mutations in the three-dimensional structure of HIV-1 reverse transcriptase. Implications for mechanisms of drug inhibition and resistance.
Journal of molecular biology - 28 Oct 1994
Tantillo C, Ding J, Jacobo-Molina A, Nanni R G, Boyer P L, Hughes S H, Pauwels R, Andries K, Janssen P A, Arnold E
Abstract excerpt
The locations of HIV-1 RT nucleoside and non-nucleoside inhibitor-binding sites and inhibitor-resistance mutations are analyzed in the context of the three-dimensional structure of the enzyme and implications for mechanisms of drug inhibition and resistance are discussed. In order to help identify residues that may play a role in inhibitor binding, solvent accessibilities of amino acids that comprise the...
Topics
- Amino Acid Sequence
- Antiviral Agents
- Binding Sites
- Drug Resistance, Microbial
- HIV Reverse Transcriptase
- HIV-1
- Humans
- Models, Molecular
- Molecular Sequence Data
- Mutation