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Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse Transcriptase

15 May 2001

Abstract excerpt

Two distinct mechanisms can be envisioned for resistance of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) to nucleoside analogs: one in which the mutations interfere with the ability of HIV-1 RT to incorporate the analog, and the other in which the mutations enhance the excision of the analog after it has been incorporated. It has been clear for some time that there are mutations that...

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PMID: 11312355
DOI: 10.1128/jvi.75.10.4832-4842.2001

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Selective Excision of AZTMP by Drug-Resistant Human Immunodeficiency Virus Reverse TranscriptasePMID 11312355Read ↗

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A mechanism of AZT resistance: an increase in nucleotide-dependent primer unblocking by mutant HIV-1 reverse transcriptase.Semantic proximity Read ↗

The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.Semantic proximity Read ↗

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HIV-1 and HIV-2 Reverse Transcriptases: Different Mechanisms of Resistance to Nucleoside Reverse Transcriptase InhibitorsSemantic proximity Read ↗

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