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Article

Mutations in the S4-H2 loop of eIF4E which increase the affinity for m7GTP.

FEBS letters - 10 Apr 2002

Spivak-Kroizman Taly, Friedland Diana E, De Staercke Christine, Gernert Kim M, Goss Dixie J, Hagedorn Curt H

Abstract excerpt

Eukaryotic initiation factor 4E (eIF4E) binds the 5'-cap of eukaryotic mRNAs and overexpression of eIF4E in epithelial cell cancers correlates with the metastases/tissue invasion phenotype. Photolabeling of eIF4E with [gamma-32P]8-azidoguanosine 5'-triphosphate (8-N3GTP) demonstrated cross-linking at Lys-119 in the S4-H2 loop which is distant from the m7GTP binding site [Marcotrigiano et al. (1997) Cell 89,...

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PMID: 11959093
DOI: 10.1016/s0014-5793(02)02445-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Mutations in the S4-H2 loop of eIF4E which increase the affinity for m7GTP.PMID 11959093Read ↗

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