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Article

Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.

Journal of molecular biology - 4 May 2007

Rosettani Pamela, Knapp Stefan, Vismara Maria-Grazia, Rusconi Luisa, Cameron Alexander D

Abstract excerpt

All eukaryotic cellular mRNAs contain a 5' m(7)GpppN cap. In addition to conferring stability to the mRNA, the cap is required for pre-mRNA splicing, nuclear export and translation by providing an anchor point for protein binding. In translation, the interaction between the cap and the eukaryotic initiation factor 4E (eIF4E) is important in the recruitment of the mRNAs to the ribosome. Human 4EHP (h4EHP) is a...

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Identifiers

PMID: 17368478
DOI: 10.1016/j.jmb.2007.02.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Structures of the human eIF4E homologous protein, h4EHP, in its m7GTP-bound and unliganded forms.PMID 17368478Read ↗

Cloning and Characterization of 4EHP, a Novel Mammalian eIF4E-related Cap-binding ProteinSemantic proximity Read ↗

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The Structures of eIF4E-eIF4G Complexes Reveal an Extended Interface to Regulate Translation Initiation.Semantic proximity Read ↗

Structure of eIF4E in Complex with an eIF4G Peptide Supports a Universal Bipartite Binding Mode for Protein Translation.Semantic proximity Read ↗

Importance of C-terminal flexible region of 4E-binding protein in binding with eukaryotic initiation factor 4E.Semantic proximity Read ↗

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