Article
Thin filament near-neighbour regulatory unit interactions affect rabbit skeletal muscle steady-state force-Ca(2+) relations.
The Journal of physiology - 15 Apr 2002
Regnier Michael, Rivera Anthony J, Wang Chien-Kao, Bates Mandy A, Chase P Bryant, Gordon Albert M
Abstract excerpt
The role of cooperative interactions between individual structural regulatory units (SUs) of thin filaments (7 actin monomers : 1 tropomyosin : 1 troponin complex) on steady-state Ca(2+)-activated force was studied. Native troponin C (TnC) was extracted from single, de-membranated rabbit psoas fibres and replaced by mixtures of purified rabbit skeletal TnC (sTnC) and recombinant rabbit sTnC (D27A, D63A), which...
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