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Article

Enhanced Ca2+ binding of cardiac troponin reduces sarcomere length dependence of contractile activation independently of strong crossbridges.

American journal of physiology. Heart and circulatory physiology - 1 Oct 2012

Korte F Steven, Feest Erik R, Razumova Maria V, Tu An-Yue, Regnier Michael

Abstract excerpt

Calcium sensitivity of the force-pCa relationship depends strongly on sarcomere length (SL) in cardiac muscle and is considered to be the cellular basis of the Frank-Starling law of the heart. SL dependence may involve changes in myofilament lattice spacing and/or myosin crossbridge orientation to increase probability of binding to actin at longer SLs. We used the L48Q cardiac troponin C (cTnC) variant, which has...

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Identifiers

PMID: 22865385
DOI: 10.1152/ajpheart.00395.2012
PMCID: PMC3469702

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