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Article

Ca2+ regulation of rabbit skeletal muscle thin filament sliding: role of cross-bridge number.

Biophysical journal - 1 Sept 2003

Liang Bo, Chen Ying, Wang Chien-Kao, Luo Zhaoxiong, Regnier Michael, Gordon Albert M, Chase P Bryant

Abstract excerpt

We investigated how strong cross-bridge number affects sliding speed of regulated Ca(2+)-activated, thin filaments. First, using in vitro motility assays, sliding speed decreased nonlinearly with reduced density of heavy meromyosin (HMM) for regulated (and unregulated) F-actin at maximal Ca(2+)....

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Identifiers

PMID: 12944292
DOI: 10.1016/S0006-3495(03)74607-4
PMCID: PMC1303351

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12944292-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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