Article
Fast skeletal muscle troponin T increases the cooperativity of transgenic mouse cardiac muscle contraction.
The Journal of physiology - 1 Oct 1999
Huang Q Q, Brozovich F V, Jin J P
Abstract excerpt
1. To investigate the functional significance of different troponin T (TnT) isoforms in the Ca2+ activation of muscle contraction, transgenic mice have been constructed with a chicken fast skeletal muscle TnT transgene driven by a cardiac alpha-myosin heavy chain gene promoter. 2. Cardiac muscle-specific expression of the fast skeletal muscle TnT has been obtained with significant myofibril incorporation....
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