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Article

c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interaction.

Cancer research - 15 Apr 2002

Couillard Martin, Guillaume Richard, Tanji Nozomu, D'Agati Vivette, Trudel Marie

Abstract excerpt

Apoptosis is a critical early cellular event in the development of polycystic kidney disease (PKD) in humans and mice. In the SBM transgenic model of PKD, both apoptosis and proliferation are c-myc driven and are independent of p53 and Bcl-2 pathways. On the basis of recent evidence implicating the FasL/Fas pathway in c-myc-induced apoptosis, we investigated the potential interaction of these pathways in vivo. We...

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PMID: 11956070

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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