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Article

Generation and Characterization of Smac/DIABLO-Deficient Mice

1 May 2002

Abstract excerpt

The mitochondrial proapoptotic protein Smac/DIABLO has recently been shown to potentiate apoptosis by counteracting the antiapoptotic function of the inhibitor of apoptosis proteins (IAPs). In response to apoptotic stimuli, Smac is released into the cytosol and promotes caspase activation by binding to IAPs, thereby blocking their function. These observations have suggested that Smac is a new regulator of...

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PMID: 11971981
DOI: 10.1128/mcb.22.10.3509-3517.2002

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Generation and Characterization of Smac/DIABLO-Deficient MicePMID 11971981Read ↗

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Unlike Diablo/smac, Grim promotes global ubiquitination and specific degradation of X chromosome-linked inhibitor of apoptosis (XIAP) and neither cause apoptosis.Semantic proximity Read ↗

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Smac induces cytochrome c release and apoptosis independently from Bax/Bcl-x(L) in a strictly caspase-3-dependent manner in human carcinoma cells.Semantic proximity Read ↗

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