Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent.

The Journal of experimental medicine - 1 Dec 1997

Trudel M, Lanoix J, Barisoni L, Blouin M J, Desforges M, L'Italien C, D'Agati V

Abstract excerpt

The SBM mouse is a unique transgenic model of polycystic kidney disease (PKD) induced by the dysregulated expression of c-myc in renal tissue. In situ hybridization analysis demonstrated intense signal for the c-myc transgene overlying tubular cystic epithelium in SBM mice. Renal proliferation index in SBM kidneys was 10-fold increased over nontransgenic controls correlating with the presence of epithelial...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Division
Share to Crosses, Genetic
Share to Disease Models, Animal

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression

Share to Genes, p53

Share to Mice, Transgenic

Share to Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 9382886
DOI: 10.1084/jem.186.11.1873
PMCID: PMC2199149

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 10 closest

C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent.PMID 9382886Read ↗

c-myc-induced apoptosis in polycystic kidney disease is independent of FasL/Fas interaction.Semantic proximity Read ↗

Disappearance of polycystic kidney disease in revertant c-myc transgenic mice.Semantic proximity Read ↗

Enhanced apoptotic cell death of renal epithelial cells in mice lacking transcription factor AP-2beta.Semantic proximity Read ↗

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.Semantic proximity Read ↗

p53-independent apoptosis during mammary tumor progression in C3(1)/SV40 large T antigen transgenic mice: suppression of apoptosis during the transition from preneoplasia to carcinoma.Semantic proximity Read ↗

Fas-independent apoptosis in T-cell tumours induced by the CD2-myc transgene.Semantic proximity Read ↗

Elevated proto-oncogene expression in polycystic kidneys of the C57BL/6J (cpk) mouse.Semantic proximity Read ↗

Calcineurin functions in Ca(2+)-activated cell death in mammalian cells.Semantic proximity Read ↗

Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity.Semantic proximity Read ↗

Generation and Characterization of Smac/DIABLO-Deficient MiceSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.