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Article

Caspase-3 Gene Deletion Prolongs Survival in Polycystic Kidney Disease

13 Feb 2008

Abstract excerpt

Pan-caspase inhibition reduces tubular apoptosis and proliferation and slows progression of disease in a rat model of polycystic kidney disease (PKD). It is unknown, however, which specific caspases are involved in PKD progression. Because caspase-3 is a major mediator of apoptosis, its role in

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Identifiers

PMID: 18272845
DOI: 10.1681/asn.2006121378

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