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Article

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.

Cell death and differentiation - 1 Jul 2006

Hughes P, Robati M, Lu W, Zhou J, Strasser A, Bouillet P

Abstract excerpt

We have recently demonstrated that ablation of one or both alleles of the proapoptotic gene Bim prevents the polycystic kidney disease (PKD) that develops in mice deficient for the prosurvival protein Bcl-2. The aim of the present study was to investigate whether loss of Bim or Bcl-2 could influence the disease in the PKD1del34/del34 mutant mice, a model of autosomal dominant PKD. PKD1del34/del34 mice were...

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Identifiers

PMID: 16282979
DOI: 10.1038/sj.cdd.4401815
PMCID: PMC2795698

Genes

PKD1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of PKD1 and loss of Bcl-2 elicit polycystic kidney disease through distinct mechanisms.PMID 16282979Read ↗

The impact of genetic background and Bid on the phenotype of Bcl-2-deficiency in mice.Semantic proximity Read ↗

Genetic interaction studies link autosomal dominant and recessive polycystic kidney disease in a common pathway.Semantic proximity Read ↗

Degenerative disorders caused by Bcl-2 deficiency prevented by loss of its BH3-only antagonist Bim.Semantic proximity Read ↗

A constitutive BCL2 down-regulation aggravates the phenotype of PKD1-mutant-induced polycystic kidney disease.Semantic proximity Read ↗

The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues.Semantic proximity Read ↗

Somatic inactivation of Pkd2 results in polycystic kidney disease.Semantic proximity Read ↗

Polycystin-1, the gene product of PKD1, induces resistance to apoptosis and spontaneous tubulogenesis in MDCK cells.Semantic proximity Read ↗

bcl-2 deficiency in mice leads to pleiotropic abnormalities: accelerated lymphoid cell death in thymus and spleen, polycystic kidney, hair hypopigmentation, and distorted small intestine.Semantic proximity Read ↗

Bcl-2-deficient mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair.Semantic proximity Read ↗

Cystogenesis in ARPKD results from increased apoptosis in collecting duct epithelial cells of Pkhd1 mutant kidneys.Semantic proximity Read ↗

Loss of the Birt–Hogg–Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcriptionSemantic proximity Read ↗

PKD1 induces p21(waf1) and regulation of the cell cycle via direct activation of the JAK-STAT signaling pathway in a process requiring PKD2.Semantic proximity Read ↗

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