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Article

Caspase-6 gene disruption reveals a requirement for lamin A cleavage in apoptotic chromatin condensation.

The EMBO journal - 15 Apr 2002

Ruchaud Sandrine, Korfali Nadia, Villa Pascal, Kottke Timothy J, Dingwall Colin, Kaufmann Scott H, Earnshaw William C

Abstract excerpt

To study the role of caspase-6 during nuclear disassembly, we generated a chicken DT40 cell line in which both alleles of the caspase-6 gene were disrupted. No obvious morphological differences were observed in the apoptotic process in caspase-6- deficient cells compared with the wild type. However, examination of apoptosis in a cell-free system revealed a block in chromatin condensation and apoptotic body...

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Identifiers

PMID: 11953316
DOI: 10.1093/emboj/21.8.1967
PMCID: PMC125972

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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