Article
Multiple pathways are involved in DNA degradation during keratinocyte terminal differentiation.
Cell death & disease - 17 Apr 2014
Yamamoto-Tanaka M, Makino T, Motoyama A, Miyai M, Tsuboi R, Hibino T
Abstract excerpt
Loss of the nucleus is a critical step in keratinocyte terminal differentiation. To elucidate the mechanisms involved, we focused on two characteristic events: nuclear translocation of N-terminal fragment of profilaggrin and caspase-14-dependent degradation of the inhibitor of caspase-activated DNase (ICAD). First, we demonstrated that epidermal mesotrypsin liberated a 55-kDa N-terminal fragment of profilaggrin...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.