Article
Caspase cleavage of MST1 promotes nuclear translocation and chromatin condensation.
Proceedings of the National Academy of Sciences of the United States of America - 28 Aug 2001
Ura S, Masuyama N, Graves J D, Gotoh Y
Abstract excerpt
MST1, mammalian STE20-like kinase 1, is a serine/threonine kinase that is cleaved and activated by caspases during apoptosis. MST1 is capable of inducing apoptotic morphological changes such as chromatin condensation upon overexpression. In this study, we show that MST1 contains two functional nuclear export signals (NESs) in the C-terminal domain, which is released from the N-terminal kinase domain upon...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.