Studies on the role of the metK gene product of Escherichia coli K-12.

doi:10.1046/j.1365-2958.2002.02856.x

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Article

Studies on the role of the metK gene product of Escherichia coli K-12.

Molecular microbiology - 1 Mar 2002

Wei Yuhong, Newman E B

Abstract excerpt

We show here that the metK gene is essential to the growth of Escherichia coli K-12 and can be deleted only in the presence of a rescue plasmid carrying a functional metK gene. When metK expression was limited, genomic DNA methylation decreased and cell division was hampered. Through primer extension, the transcription start site of metK was located at 140 bp upstream of the translation start site. The frequently...

Topics

Base Sequence
Culture Media
DNA Methylation
Escherichia coli
Glucose
Methionine Adenosyltransferase
Molecular Sequence Data
Mutation
Promoter Regions, Genetic
S-Adenosylmethionine
Transcription, Genetic

Source

Open in PubMed

Identifiers

PMID: 11952912
DOI: 10.1046/j.1365-2958.2002.02856.x

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