Article
Novel Escherichia coli K-12 mutants impaired in S-adenosylmethionine synthesis.
Journal of bacteriology - 1 Aug 1990
Satishchandran C, Taylor J C, Markham G D
Abstract excerpt
S-Adenosylmethionine (AdoMet) plays a myriad of roles in cellular metabolism. One of the many roles of AdoMet in Escherichia coli and Salmonella typhimurium is as a corepressor of genes encoding enzymes of methionine biosynthesis. To investigate the metabolic effects of large reductions in intracellular AdoMet concentrations in growing cells, we constructed and examined mutants of E. coli which are conditionally...
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