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Article

The S(MK) box is a new SAM-binding RNA for translational regulation of SAM synthetase.

Nature structural & molecular biology - 1 Mar 2006

Fuchs Ryan T, Grundy Frank J, Henkin Tina M

Abstract excerpt

We have identified the S(MK) box as a conserved RNA motif in the 5' untranslated leader region of metK (SAM synthetase) genes in lactic acid bacteria, including Enterococcus, Streptococcus and Lactococcus species. This RNA element bound SAM in vitro, and binding of SAM caused an RNA structural rearrangement that resulted in sequestration of the Shine-Dalgarno (SD) sequence. Mutations that disrupted pairing...

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Identifiers

PMID: 16491091
DOI: 10.1038/nsmb1059

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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