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Article

Expression of human beta-secretase in the mouse brain increases the steady-state level of beta-amyloid.

Journal of neurochemistry - 1 Mar 2002

Bodendorf Ursula, Danner Simone, Fischer Frauke, Stefani Muriel, Sturchler-Pierrat Christine, Wiederhold Karl-Heinz, Staufenbiel Matthias, Paganetti Paolo

Abstract excerpt

beta-Site APP-cleaving enzyme (BACE) initiates the processing of the amyloid precursor protein (APP) leading to the generation of beta-amyloid, the main component of Alzheimer's disease senile plaques. BACE (Asp2, memapsin 2) is a type I transmembrane aspartyl protease and is responsible for the beta-secretase cleavage of APP producing different endoproteolytic fragments referred to as the carboxy-terminal C99,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11948243
DOI: 10.1046/j.0022-3042.2002.00770.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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