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Article

BACE/APPV717F double-transgenic mice develop cerebral amyloidosis and inflammation.

Neuro-degenerative diseases - 1 Jan 2005

Ozmen Laurence, Woolley Marie, Albientz Anita, Miss Marie-Therese, Nelboeck Peter, Malherbe Pari, Czech Christian, Gruninger-Leitch Fiona, Brockhaus Manfred, Ballard Theresa, Jacobsen Helmut

Abstract excerpt

Most of the transgenic mice generated to model Alzheimer's disease express human amyloid precursor protein (APP) mutants alone or in conjunction with presenilin mutants. We have generated a mouse model by overexpressing human BACE and human APP with the V717F mutation. The combination of a mutation at the gamma-secretase cleavage site of APP and of increased beta-secretase activity should favour the production of...

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Identifiers

PMID: 16909011
DOI: 10.1159/000092314

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APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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