Article
Homocysteine and methylenetetrahydrofolate reductase genotype: association with risk of coronary heart disease and relation to inflammatory, hemostatic, and lipid parameters.
Atherosclerosis - 1 May 2002
Rothenbacher D, Fischer H G, Hoffmeister A, Hoffmann M M, März W, Bode G, Rosenthal J, Koenig W, Brenner H
Abstract excerpt
AIM: It has been suggested that homocysteine (tHcy) levels and methylenetetrahydrofolate reductase (MTHFR) genotype are primary risk factors for coronary heart disease (CHD). We performed a case-control study to investigate whether tHcy levels and MTHFR genotype (677 C-->T mutation and 1298 A-->C mutation) are associated with CHD under special consideration of the possibility for confounding. METHODS: German...
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