Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Aug 2003

Cohen Yoram, Singer Gad, Lavie Ofer, Dong Seung Myung, Beller Uziel, Sidransky David

Abstract excerpt

PURPOSE: Development of adenocarcinoma (AC) of the uterine cervix, as well as squamous cell carcinoma (SCC), is strongly linked to infection by high-risk human papillomavirus (HPV) types. Human HPV E6 and E7 proteins inactivate the tumor suppressor genes p53 and retinoblastoma, respectively. However, additional genetic alterations may be required to maintain a malignant phenotype. Allelic loss at the short arm of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carcinoma, Squamous Cell
Share to Gene Silencing

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Oncogene Proteins, Viral

Share to Papillomaviridae

Share to Papillomavirus E7 Proteins

Share to Sulfites

Share to Tumor Suppressor Proteins

Share to Uterine Cervical Neoplasms

Source

Identifiers

PMID: 12912945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The RASSF1A tumor suppressor gene is commonly inactivated in adenocarcinoma of the uterine cervix.PMID 12912945Read ↗

Hypermethylation of the tumor suppressor gene RASSFIA and frequent concomitant loss of heterozygosity at 3p21 in cervical cancers.Semantic proximity Read ↗

Hypermethylation of two consecutive tumor suppressor genes, BLU and RASSF1A, located at 3p21.3 in cervical neoplasias.Semantic proximity Read ↗

Inverse correlation between RASSF1A hypermethylation, KRAS and BRAF mutations in cervical adenocarcinoma.Semantic proximity Read ↗

The tumor suppressor RASSF1A in human carcinogenesis: an update.Semantic proximity Read ↗

Epigenetic inactivation of RASSF1A in lung and breast cancers and malignant phenotype suppression.Semantic proximity Read ↗

Frequent epigenetic inactivation of RASSF1A by aberrant promoter hypermethylation in human gastric adenocarcinoma.Semantic proximity Read ↗

Hypermethylation of the cpG island of Ras association domain family 1A (RASSF1A), a putative tumor suppressor gene from the 3p21.3 locus, occurs in a large percentage of human breast cancers.Semantic proximity Read ↗

RASSF1A gene inactivation in non-small cell lung cancer and its clinical implication.Semantic proximity Read ↗

Aberrant promoter methylation and loss of suppressor of cytokine signalling-1 gene expression in the development of uterine cervical carcinogenesis.Semantic proximity Read ↗

Clinicopathological significance of epigenetic inactivation of RASSF1A at 3p21.3 in stage I lung adenocarcinoma.Semantic proximity Read ↗

Association between Ras association domain family 1A promoter methylation and esophageal squamous cell carcinoma: a meta-analysis.Semantic proximity Read ↗

Frequent hypermethylation of promoter region of <i>RASSF1A</i> in tumor tissues and voided urine of urinary bladder cancer patientsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.