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Article

Frequent hypermethylation of 5' flanking region of TIMP-2 gene in cervical cancer.

International journal of cancer - 1 Mar 2004

Ivanova Tatyana, Vinokurova Svetlana, Petrenko Anatolii, Eshilev Ernest, Solovyova Nina, Kisseljov Fjodor, Kisseljova Natalia

Abstract excerpt

Tissue inhibitor of metalloproteinase-2 (TIMP-2) is an endogenous inhibitor of matrix metalloproteinases (MMPs). This multifunctional protein regulates activities of MMPs and possesses growth promoting effect in cell culture, anti-tumoral, anti-apoptotic and anti-angiogenic effects in animal model systems in vivo. It has been shown that this gene is downregulated in cervical carcinomas. The mechanism of...

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PMID: 14712492
DOI: 10.1002/ijc.11652

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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