Article
Endothelial IKK beta signaling is required for monocyte adhesion under laminar flow conditions.
Journal of molecular and cellular cardiology - 1 Mar 2002
Meiler Steffen E, Hung Rebecca R, Gerszten Robert E, Gianetti Jacopo, Li Ling, Matsui Takashi, Gimbrone Michael A, Rosenzweig Anthony
Abstract excerpt
Endothelial activation induces expression of pro-inflammatory molecules that are thought to play an important role in atherogenesis through enhanced vascular monocyte recruitment. Many pro-inflammatory endothelial signals are transcriptionally regulated by members of the NF- kappa B family. The serine-threonine kinase, IKK beta, can mediate NF- kappa B activation although several alternative pathways exist. To...
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