Article
Functional inhibition of NF-kappaB signal transduction in alphavbeta3 integrin expressing endothelial cells by using RGD-PEG-modified adenovirus with a mutant IkappaB gene.
Arthritis research & therapy - 1 Jan 2006
Ogawara Ken-ichi, Kułdo Joanna M, Oosterhuis Koen, Kroesen Bart-Jan, Rots Marianne G, Trautwein Christian, Kimura Toshikiro, Haisma Hidde J, Molema Grietje
Abstract excerpt
In order to selectively block nuclear factor kappaB (NF-kappaB)-dependent signal transduction in angiogenic endothelial cells, we constructed an alphavbeta3 integrin specific adenovirus encoding dominant negative IkappaB (dnIkappaB) as a therapeutic gene. By virtue of RGD modification of the PEGylated virus, the specificity of the cell entry pathway of adenovirus shifted from coxsacki-adenovirus receptor...
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