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Article

Antimorphic PV.1 causes secondary axis by inducing ectopic organizer.

Biochemical and biophysical research communications - 12 Apr 2002

Hwang Yoo-Seok, Seo Jeong-Jae, Cha Sang-Wook, Lee Hyun-Shik, Lee Sung-Young, Roh Dong-Hyun, Kung Hf Hsiang-fu, Kim Jaebong, Ja Park Mae

Abstract excerpt

Xenopus homeobox gene, PV.1 ventralizes activin-induced dorsal mesoderm and inhibits neuralization of ectoderm in animal cap when overexpressed. Here we generated PV.1/engrailed fusion construct (N-PV1-EnR) to perform loss-of-function study for this transcription factor. N-PV1-EnR showed an extremely antimorphic effect, causing a partial secondary embryonic axis when expressed at ventral marginal zone of...

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PMID: 11944926
DOI: 10.1006/bbrc.2002.6740

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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