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Article

Active repression of organizer genes by C-terminal domain of PV.1.

Biochemical and biophysical research communications - 15 Aug 2003

Hwang Yoo-Seok, Lee Hyun-Shik, Roh Dong-Hyun, Cha Sang- Wook, Lee Sung-Young, Seo Jeong-Jae, Kim Jaebong, Park Mae Ja

Abstract excerpt

PV.1, a homeotic protein, ventralizes dorsal mesoderm and inhibits neuralization by mediating BMP-4 signaling in Xenopus embryo. In our previous report antimorphic PV.1 causes a secondary axis by inducing the ectopic organizer. We analyzed the structure of this transcription factor through domain level assessment. In a phenotype-inducing test, half of the N-terminus at the N-terminal side was unessential for...

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PMID: 12890483
DOI: 10.1016/s0006-291x(03)01321-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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