Article
Fusion of lung lobes and vessels in mouse embryos heterozygous for the forkhead box f1 targeted allele.
American journal of physiology. Lung cellular and molecular physiology - 1 May 2002
Lim Lorena, Kalinichenko Vladimir V, Whitsett Jeffrey A, Costa Robert H
Abstract excerpt
Previously, we showed that newborn forkhead box (Fox)f1(+/-) mice with diminished pulmonary FoxF1 levels died of severe lung hemorrhage and exhibited abnormal formation of alveolar sacs and capillaries. Another group recently reported that Foxf1(+/-) mouse embryos displayed a number of organ and skeletal defects including fusion of lung lobes. However, identification of pulmonary genes whose altered expression...
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