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Mitochondrial effects of the pleiotropic proteasomal mutation mpr1/rpn11: uncoupling from cell cycle defects in extragenic revertants.

Gene - 6 Mar 2002

Rinaldi T, Ricordy R, Bolotin-Fukuhara M, Frontali L

Abstract excerpt

We have previously characterized a Saccharomyces cerevisiae mutant which contains a mutation in the essential rpn11/mpr1 gene coding for the proteasomal regulatory subunit Rpn11. The mpr1-1 mutation shows the phenotypic characteristics generally associated with proteasomal mutations, such as cell cycle defects and accumulation of polyubiquitinated proteins. However, for the first time, mitochondrial defects have...

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PMID: 11943459
DOI: 10.1016/s0378-1119(01)00799-5

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