Article
Dissection of the carboxyl-terminal domain of the proteasomal subunit Rpn11 in maintenance of mitochondrial structure and function.
Molecular biology of the cell - 1 Mar 2008
Rinaldi Teresa, Hofmann Line, Gambadoro Alessia, Cossard Raynald, Livnat-Levanon Nurit, Glickman Michael H, Frontali Laura, Delahodde Agnès
Abstract excerpt
We have previously demonstrated that the C-terminal part of Rpn11, a deubiquitinating enzyme in the lid of the proteasome, is essential for maintaining a correct cell cycle and normal mitochondrial morphology and function. The two roles are apparently unlinked as the mitochondrial role is mapped to the Carboxy-terminus, whereas the catalytic deubiquitinating activity is found within the N-terminal region. The...
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