Article
Temperature-sensitive mutation in yeast mitochondrial ribosome recycling factor (RRF).
Nucleic acids research - 15 Jul 2003
Teyssier Emeline, Hirokawa Go, Tretiakova Anna, Jameson Bradford, Kaji Akira, Kaji Hideko
Abstract excerpt
The yeast protein Rrf1p encoded by the FIL1 nuclear gene bears significant sequence similarity to Escherichia coli ribosome recycling factor (RRF). Here, we call FIL1 Ribosome Recycling Factor of yeast, RRF1. Its gene product, Rrf1p, was localized in mitochondria. Deletion of RRF1 leads to a respiratory incompetent phenotype and to instability of the mitochondrial genome (conversion to rho(-)/rho(0) cytoplasmic...
Topics
- Cell Division
- DNA, Mitochondrial
- Electron Transport
- Gene Deletion
- Genetic Complementation Test
- Mitochondria
- Mitochondrial Proteins
- Mutation
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Temperature