Article
Lack of association between a polymorphism in the interleukin-13 gene and total serum immunoglobulin E level among nuclear families in Costa Rica.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Mar 2002
Celedón J C, Soto-Quiros M E, Palmer L J, Senter J, Mosley J, Silverman E K, Weiss S T
Abstract excerpt
BACKGROUND: IL-13 has been implicated in the pathogenesis of asthma and in the regulation of IgE synthesis in humans. Single nucleotide polymorphisms (SNPs) in the IL-13 gene have been associated with asthma and total serum IgE level in Caucasian populations. OBJECTIVE: To test for genetic association between an SNP in exon 4 of the IL-13 gene (IL-13 + 2044 or Arg130Gln) and total serum IgE level and...
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