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Article

Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.

Developmental cell - 22 Dec 2014

Clough Emily, Jimenez Erin, Kim Yoo-Ah, Whitworth Cale, Neville Megan C, Hempel Leonie U, Pavlou Hania J, Chen Zhen-Xia, Sturgill David, Dale Ryan K, Smith Harold E, Przytycka Teresa M, Goodwin Stephen F, Van Doren Mark, Oliver Brian

Abstract excerpt

Primary sex-determination "switches" evolve rapidly, but Doublesex (DSX)-related transcription factors (DMRTs) act downstream of these switches to control sexual development in most animal species. Drosophila dsx encodes female- and male-specific isoforms (DSX(F) and DSX(M)), but little is known about how dsx controls sexual development, whether DSX(F) and DSX(M) bind different targets, or how DSX proteins direct...

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Source

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Identifiers

PMID: 25535918
DOI: 10.1016/j.devcel.2014.11.021
PMCID: PMC4275658

Genes

DMRT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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