Article
Sex- and tissue-specific functions of Drosophila doublesex transcription factor target genes.
Developmental cell - 22 Dec 2014
Clough Emily, Jimenez Erin, Kim Yoo-Ah, Whitworth Cale, Neville Megan C, Hempel Leonie U, Pavlou Hania J, Chen Zhen-Xia, Sturgill David, Dale Ryan K, Smith Harold E, Przytycka Teresa M, Goodwin Stephen F, Van Doren Mark, Oliver Brian
Abstract excerpt
Primary sex-determination "switches" evolve rapidly, but Doublesex (DSX)-related transcription factors (DMRTs) act downstream of these switches to control sexual development in most animal species. Drosophila dsx encodes female- and male-specific isoforms (DSX(F) and DSX(M)), but little is known about how dsx controls sexual development, whether DSX(F) and DSX(M) bind different targets, or how DSX proteins direct...
Topics
- Animals
- Animals, Genetically Modified
- Binding Sites
- DNA-Binding Proteins
- Drosophila Proteins
- Drosophila melanogaster
- Female
- Gene Expression Profiling
- Gene Expression Regulation