Article
Translational errors as an early event in prion conversion.
Cellular and molecular biology (Noisy-le-Grand, France) - 1 Jan 2001
Hatin I, Bidou L, Cullin C, Rousset J P
Abstract excerpt
A prion is an infectious, altered form of a cellular protein which can self-propagate and affect normal phenotype. Prion conversion has been observed for mammalian and yeast proteins but molecular mechanisms that trigger this process remain unclear. Up to now, only post-translational models have been explored. In this work, we tested the hypothesis that co-translational events may be implicated in the...
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