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Article

The [URE3] yeast prion: from genetics to biochemistry.

Biochemistry. Biokhimiia - 1 Dec 1999

Komar A A, Melki R, Cullin C

Abstract excerpt

[URE3] is a non-Mendelian genetic element of the yeast Saccharomyces cerevisiae, an altered prion form of Ure2 protein. We show that recombinant Ure2p is a soluble protein that can assemble in vitro into dimers, tetramers, and octamers or form insoluble fibrils observed for PrP in its filamentous form or for Sup35p upon self-assembling, suggesting a similar mechanism for all prions. Computational, genetic,...

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PMID: 10648964

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