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The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2

9 Mar 2017

Abstract excerpt

ABSTRACT Human papillomaviruses (HPV) replicate their genomes in differentiating epithelium using the viral proteins E1 and E2 in association with host proteins. While the roles of E1 and E2 in this process are understood, the host factors involved and how they interact with and regulate E1-E2 are not. Our previous work identified the host replication and repair factor TopBP1 as an E2 partner protein essential...

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PMID: 28275188
DOI: 10.1128/jvi.00102-17

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