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TopBP1 Regulates Human Papillomavirus Type 16 E2 Interaction with Chromatin

8 Feb 2007

Abstract excerpt

Human papillomavirus type 16 (HPV16) E2 regulates transcription from and replication of the viral genome, in association with viral and cellular factors. HPV16 E2 interacts functionally with TopBP1, a cellular protein essential for the initiation of cellular, and potentially viral, DNA replication. This report demonstrates that the absence of TopBP1 results in the redistribution of HPV16 E2 into an alternative...

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PMID: 17287259
DOI: 10.1128/jvi.02353-06

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TopBP1 Regulates Human Papillomavirus Type 16 E2 Interaction with ChromatinPMID 17287259Read ↗

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation functionSemantic proximity Read ↗

Evidence Supporting a Role for TopBP1 and Brd4 in the Initiation but Not Continuation of Human Papillomavirus 16 E1/E2-Mediated DNA ReplicationSemantic proximity Read ↗

Interaction with TopBP1 Is Required for Human Papillomavirus 16 E2 Plasmid Segregation/Retention Function during MitosisSemantic proximity Read ↗

An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome EstablishmentSemantic proximity Read ↗

A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levelsSemantic proximity Read ↗

A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels and activates the DNA damage responseSemantic proximity Read ↗

A Functional Interaction between the Human Papillomavirus 16 Transcription/Replication Factor E2 and the DNA Damage Response Protein TopBP1Semantic proximity Read ↗

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycleSemantic proximity Read ↗

CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention functionSemantic proximity Read ↗

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life CycleSemantic proximity Read ↗

Brd4 Is Required for E2-Mediated Transcriptional Activation but Not Genome Partitioning of All PapillomavirusesSemantic proximity Read ↗

Human Papillomavirus 16 E2 Interaction with TopBP1 Is Required for E2 and Viral Genome Stability during the Viral Life CycleSemantic proximity Read ↗

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