Article

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycle

2023-01-13

Abstract excerpt

CK2 phosphorylation of HPV16 E2 at serine 23 promotes interaction with TopBP1, and this interaction is important for E2 plasmid segregation function. Here we demonstrate that the E2-TopBP1 interaction is critical for E2 and viral genome stability during the viral life cycle. Introduction of the S23A mutation into the HPV16 genome results in a loss of E2 expression and viral genome integration during organotypic ra...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fe6ec363-6e28-5b38-aa7d-49611f689df1
DOI: 10.1101/2023.01.11.523702

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycleDOI 10.1101/2023.01.11.523702Read

Human Papillomavirus 16 E2 Interaction with TopBP1 Is Required for E2 and Viral Genome Stability during the Viral Life CycleSemantic proximity Read

CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 plasmid retention functionSemantic proximity Read

An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome EstablishmentSemantic proximity Read

A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levelsSemantic proximity Read

CK2 Phosphorylation of Human Papillomavirus 16 E2 on Serine 23 Promotes Interaction with TopBP1 and Is Critical for E2 Interaction with Mitotic Chromatin and the Viral Life CycleSemantic proximity Read

A human papillomavirus 16 E2-TopBP1 dependent SIRT1-p300 acetylation switch regulates mitotic viral and human protein levels and activates the DNA damage responseSemantic proximity Read

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation functionSemantic proximity Read

Evidence Supporting a Role for TopBP1 and Brd4 in the Initiation but Not Continuation of Human Papillomavirus 16 E1/E2-Mediated DNA ReplicationSemantic proximity Read

The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2Semantic proximity Read

A critical role for E2-p53 interaction during the HPV16 life cycleSemantic proximity Read

E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cyclesSemantic proximity Read

A Functional Interaction between the Human Papillomavirus 16 Transcription/Replication Factor E2 and the DNA Damage Response Protein TopBP1Semantic proximity Read