Article
Mutations in the human papillomavirus type 16 E2 protein identify multiple regions of the protein involved in binding to E1.
The Journal of general virology - 1 Nov 1995
Piccini A, Storey A, Massimi P, Banks L
Abstract excerpt
Human papillomavirus type 16 (HPV-16) DNA replicates episomally and requires two virally expressed proteins, E1 and E2. The E1 protein has both helicase and ATPase activities and is absolutely required for viral DNA replication. The E2 protein is a potent transcriptional activator and greatly inc...
Topics
- Binding Sites
- Cell Line
- DNA-Binding Proteins
- Defective Viruses
- Gene Expression Regulation, Viral
- Humans
- Mutation
- Oncogene Proteins, Fusion
- Oncogene Proteins, Viral
- Papillomaviridae
- Protein Binding
- Transcriptional Activation